The current study aimed to estimate the active compounds of pomegranate (Punica granatum) and garlic (Allium sativum) peel extracts using high-performance liquid chromatography (HPLC) and to evaluate their inhibitory activity against the fungus Trichophyton mentagrophytes isolated from human skin lesions compared to the standard antibiotic griseofulvin. HPLC analysis revealed chemical diversity in the plant extracts used. Pomegranate peel extract showed a predominance of punicalagin (244.6 ppm) followed by tannic acid (128.9 ppm), while garlic extract was characterized by an effective concentration of allicin (4120 ppm), in addition to quercetin and rutin. The findings of the biological effect test using agar well diffusion method demonstrated a highly significant (P≤0.01) effect for the plant extracts at 100% concentration. Pomegranate peel extract showed the highest inhibitory diameter (13 mm) followed by garlic extract (10 mm). Both extracts were more effective than the fungal fungicide Griseofulvin (8 mm). Statistical evaluation through the least significant difference (LSD) test showed a positive relationship between the concentration of the extracts and their inhibitory effect, thus confirming the synergistic action of the phytochemicals in the disruption of the fungal cell wall and the inhibition of the fungal pathogenic enzymes. This study concludes that plant extracts possess promising in vitro inhibitory efficacy against the fungus Trichophyton mentagrophytes ,opening new avenues for their utilization as natural and therapeutic alternatives for its control