Backgroud: Hyperglycemia in diabetes promotes Hypoxia leading to alterations in the cellular microenvironment, Hypoxia triggers adaptive cellular responses, which is largely regulated via a transcription factor termed Hypoxia- inducible factor 1 -alpha (HIF-1α), in addition Hypoxia influence Cell death pathways through stabilization of the tumor suppressor factor p53.Aims: our study aims to evaluate the implication of the genetic expression of hypoxia inducible factor (HIF-1α) in regulating p53 signaling in in individuals with T2DM in comparison with the non-diabetic control group. Methods: Whole blood was obtained from both T2DM and non-diabetic participants, followed by qPCR to estimate the relative transcriptional levels of (HIF-1α and P53).Results: The results showed a significant up regulation of gene expression of (HIF-1α and P53 ).in the patient relative to the control group, Analysis of covariance revealed that over model for (HIF-1α and P53 ) expression were statically significant, while diabetes ,gender and body mas index(BMI) did not showed significant no dependent effects, additionally a notable positive correlation was detected between expression of ( HIF-1α and P53) . Conclusion : The study illustrated that a potential impact of the HIF-1α signaling in inducing cell apoptosis through upregulating of p53 therefore, these results provide evidence that HIF-1α and p53 could act as interconnected cellular markers and support further investigation in expanded cohorts.
Ameen,A Abul Jabbar, mazyed,Z abdulkadhim and Ali,S Fadhil. (2026). Hypoxia induces apoptosis in blood cells through activating P53 in Diabetes patients. Al-Kunooze Scientific Journal, 12(3), 31-45. doi: 10.36582/ksj.2026.170052.1034
MLA
Ameen,A Abul Jabbar, , mazyed,Z abdulkadhim, and Ali,S Fadhil. "Hypoxia induces apoptosis in blood cells through activating P53 in Diabetes patients", Al-Kunooze Scientific Journal, 12, 3, 2026, 31-45. doi: 10.36582/ksj.2026.170052.1034
HARVARD
Ameen A Abul Jabbar, mazyed Z abdulkadhim, Ali S Fadhil. (2026). 'Hypoxia induces apoptosis in blood cells through activating P53 in Diabetes patients', Al-Kunooze Scientific Journal, 12(3), pp. 31-45. doi: 10.36582/ksj.2026.170052.1034
CHICAGO
A Abul Jabbar Ameen, Z abdulkadhim mazyed and S Fadhil Ali, "Hypoxia induces apoptosis in blood cells through activating P53 in Diabetes patients," Al-Kunooze Scientific Journal, 12 3 (2026): 31-45, doi: 10.36582/ksj.2026.170052.1034
VANCOUVER
Ameen A Abul Jabbar, mazyed Z abdulkadhim, Ali S Fadhil. Hypoxia induces apoptosis in blood cells through activating P53 in Diabetes patients. KSJ. 2026;12(3):31-45. doi: 10.36582/ksj.2026.170052.1034
