Al-Kunooze Scientific Journal

Gut Microbiome and Breast Cancer: A Concise Review

Document Type : Review

Authors

Yasameen Hameed Jasim 1
Ashraq Monir Mahmed 2
Rasha Hameed Jasim 3
Mustafa Abd- almajeed Abd-alkareem 3

1 Samarra

2 Department of Food Science, College of Agricultural Engineering Sciences, University of Baghdad, Iraq

3 Department of pathological analysis disease. College of Applied Sciences, Samarra University, Samarra , Iraq

https://doi.org/10.36582/ksj.2026.168874.1021
Abstract
The Gut Microbiome influences Breast Cancer risk through Estrogen Metabolism, inflammation throughout the body, and Immune System Regulation. A decrease in the diversity of microbes will result in an imbalance of the gut microbiome (dysbiosis), which will support the increase of pro-inflammatory microbes, leading to elevated Circulating Estrogens and ultimately supporting greater Tumor Growth; conversely, some beneficial microbes (such as Lactobacillus) will help maintain hormonal equilibrium, reducing the likelihood of developing breast cancer. The combination of what we eat and how we eat (diet) has a significant impact on the types of bacteria that grow and multiply within our gut microbiome. Studies show that a diet rich in Fiber and Plant-Based foods supports the growth of short-chain fatty acids. SCFAs(bacteria, while diets that are high in Fat and Sugar contribute to an increased incidence of dysbiosis and systemic inflammation. Intervening to restore a healthy balance of gut bacteria has been proven to reduce Inflammation and improve health and wellness. Personalized Interventions based on the Gut Microbiome will have tremendous potential as an additional method for Breast Cancer Prevention and Treatment.

Keywords

Breast cancer
Gut Microbiome
estrogen metabolism
inflammation
immune modulation
nutritional factors
Crossmark
Al-Kunooze Scientific Journal
Volume 12, Issue 2
Spring 2026
Pages 173-189

  • Receive Date 21 January 2026
  • Revise Date 05 March 2026
  • Accept Date 19 March 2026
  • First Publish Date 19 March 2026
  • Publish Date 01 March 2026

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