This study involved two plant species of different plant families, cumin (Cuminum cyminum) family Apiaceae and basil (Ocimum basilicum) family Lamiaceae of medical and economic importance. Aim: study luteolin o -7- glucoside in both species and evaluate its potential effect on colon cancer. Method: extraction by (70% ethanol) using (Soxhlet and reflux), high-performance liquid chromatography (HPLC) for detection of compound , and in vitro evaluation of the potential biological activity of crude plant extracts and luteolin O-7 glycoside with anticancer activity of Colon HCT Cell lines were tested using (MTT) assay. Results: of in vitro anticancer activity study conducted against colon cancer cell line showed moderate cytotoxicity of these plant extracts and luteolin 0 7 glucoside compounds against colon cancer. In which inhibition in viability of colon cancer cell by Cuminum cyminum (17.48% at concentration 250µg , 18.39 at concentration 500µg and 34 at 1000µg ) , Ocimum basilicum showed inhibition in the viability of cancer cell (17.66 at 250 µg , 26.8 500µg and 40.6 at 1000µg) While luteolin 0 - 7-glucoside stander showed decrease in the viability of cancer cell by (29.14 at 250 µg 11.11 500µg and 39 at 1000µg
Essam Hussain, Ula M. Noor AlMousawi , Hiba Abdul- Razaq, Falah Hasan Shari,F . (2024). Evaluation of Anti -Cancer Potential of luteolin 7 -o- glucoside extracted from Cuminum cyminum and Ocimum basilicum in colon Cancer Cell Line. Al-Kunooze Scientific Journal, 9(1), 68-78.
MLA
Essam Hussain, Ula M. Noor AlMousawi , Hiba Abdul- Razaq, Falah Hasan Shari,F . "Evaluation of Anti -Cancer Potential of luteolin 7 -o- glucoside extracted from Cuminum cyminum and Ocimum basilicum in colon Cancer Cell Line", Al-Kunooze Scientific Journal, 9, 1, 2024, 68-78.
HARVARD
Essam Hussain, Ula M. Noor AlMousawi , Hiba Abdul- Razaq, Falah Hasan Shari F. (2024). 'Evaluation of Anti -Cancer Potential of luteolin 7 -o- glucoside extracted from Cuminum cyminum and Ocimum basilicum in colon Cancer Cell Line', Al-Kunooze Scientific Journal, 9(1), pp. 68-78.
CHICAGO
F Essam Hussain, Ula M. Noor AlMousawi , Hiba Abdul- Razaq, Falah Hasan Shari, "Evaluation of Anti -Cancer Potential of luteolin 7 -o- glucoside extracted from Cuminum cyminum and Ocimum basilicum in colon Cancer Cell Line," Al-Kunooze Scientific Journal, 9 1 (2024): 68-78,
VANCOUVER
Essam Hussain, Ula M. Noor AlMousawi , Hiba Abdul- Razaq, Falah Hasan Shari F. Evaluation of Anti -Cancer Potential of luteolin 7 -o- glucoside extracted from Cuminum cyminum and Ocimum basilicum in colon Cancer Cell Line. KSJ. 2024;9(1):68-78.
